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Science & Core Platforms

Our Science & Technology

Integrating genomics, molecular biology, bioinformatics, and computational intelligence to personalize cancer care.

Section 06 • Oncology

Understanding Cancer Beyond the Diagnosis

Cancer is not a single disease.

Even when two patients are diagnosed with the same cancer type, their tumours can have different genetic alterations, molecular pathways and biological behaviours. Precision oncology seeks to understand these differences.

Genomics + Molecular Biology + Bioinformatics + Clinical Information

By combining these disciplines, it becomes possible to investigate the molecular characteristics of individual cancers. Shansons Precix focuses on the scientific potential of precision oncology to support:

✦ Cancer characterisation
✦ Molecular profiling
✦ Biomarker identification
✦ Mutation analysis
✦ Treatment-response research
✦ Pharmacogenetic assessment
✦ Disease monitoring
✦ Personalised therapeutic strategies
Precision Oncology Molecular Profiling
✦ MOLECULAR DRIVER PROFILING

Comprehensive genomic profiling and targeted treatment strategy selection.

Section 08 • Drug Response

Cancer Pharmacogenetics

Understanding How Genetics Influences Treatment Response.

Patients can respond differently to the same medicine. Genetic differences can influence:

  • ▸ Drug metabolism: Variations in hepatic enzymes (CYP450, DPYD, TPMT).
  • ▸ Drug transport: Membrane influx and efflux pumps affecting cellular uptake.
  • ▸ Drug targets: Receptor affinity and pathway sensitivity.
  • ▸ Treatment response & adverse effects: Mitigating severe toxicity.

Our Focus

Shansons Precix explores cancer pharmacogenetics as a pathway towards more informed treatment decisions. Our research focus includes:

Drug-response biomarkers Pharmacogenomic profiling Treatment resistance Personalised therapy research

Genotype-to-Dosing Matching

Evaluating inherited polymorphic variants to predict therapeutic window and clear drug metabolites safely:

DPYD Variants (*2A, *13) 5-FU & Capecitabine Risk
UGT1A1 (*28, *6) Irinotecan Toxicity
TPMT / NUDT15 Thiopurine Myelosuppression
CYP2D6 Poor Metabolizers Tamoxifen Efficacy Profile
Section 09 • Non-Invasive

Liquid Biopsy: A Window into Cancer Through Blood

Cancer can release biological material into the bloodstream.

Liquid biopsy explores the possibility of analysing this circulating material through a minimally invasive blood-based approach.

Potential Applications

  • ✦ Cancer mutation detection
  • ✦ Molecular profiling
  • ✦ Disease monitoring
  • ✦ Treatment-response assessment
  • ✦ Molecular changes over time
  • ✦ Minimal residual disease (MRD)
From a Blood Sample to Molecular Insight
Sample → Molecular Analysis → Genomic Information → Interpretation → Precision Medicine Insight
Liquid Biopsy Stream and Circulating Tumor DNA
✦ NON-INVASIVE DIAGNOSTICS

Real-time circulating tumor DNA tracking and disease progression monitoring.

Section 10 • Genomics

Next-Generation Sequencing (NGS)

Reading the Genetic Blueprint

Next-Generation Sequencing, or NGS, enables large amounts of genetic information to be analysed efficiently. At Shansons Precix, NGS forms an important part of our precision medicine research framework.

Applications:
Genetic profiling Cancer mutation analysis Biomarker discovery Molecular characterisation Variant identification Research applications Personalised medicine
Section 11 • Computational Biology

Bioinformatics

Turning Genomic Data Into Biological Insight

Modern sequencing technologies generate enormous amounts of biological data. The challenge is not only generating data. The challenge is understanding it. Bioinformatics provides the computational framework required to process, analyse and interpret genomic information.

Research Focus:
Sequence analysis Variant identification Genomic data processing Biomarker discovery Molecular profiling Data interpretation Computational cancer research
Data → Analysis → Interpretation → Insight
AI in Precision Medicine and Neural Biology
✦ NEURAL BIOLOGY & MACHINE INSIGHT

AI-driven variant effect prediction and computational biomarker discovery.

Section 12 • Machine Intelligence

Artificial Intelligence in Precision Medicine

Applying Intelligence to Complex Biological Data.

The growing scale of genomic and molecular datasets creates opportunities for computational and AI-driven approaches. Shansons Precix positions AI research around:

  • ✦ Genomic data interpretation & variant prioritisation
  • ✦ Pattern identification across multi-omic cohorts
  • ✦ Biomarker research and molecular classification
  • ✦ Treatment-response prediction and resistance modeling
  • ✦ Multi-dimensional molecular data integration

Where Biology Meets Computation

Our long-term vision is to explore how computational intelligence can complement genomic and molecular science to accelerate precision medicine research.

Section 13 • Diagnostics

Cancer Precision Diagnostics

Diagnose the Biology, Not Just the Disease

Cancer diagnosis is evolving beyond identifying where a tumour originated. Molecular information provides critical insight into the biological characteristics of a tumour.

Our Focus:
Molecular profiling Mutation analysis Biomarker identification Genomic characterisation Liquid biopsy research Cancer risk research Molecular disease monitoring
Our Objective: To contribute to diagnostic approaches that provide deeper biological understanding of cancer.
Section 14 • Immunogenomics

Personalized Vaccine Research

Designing the Future of Personalised Cancer Immunity

The biological characteristics of cancer can vary significantly between individuals. Personalised vaccine research explores strategies that use individual molecular characteristics to develop targeted immune-based approaches.

Research Directions:
Cancer antigen identification Individual molecular profiling Immune-response research Personalised vaccine design concepts Biomarker-driven immunology Computational antigen analysis
Emerging Frontier: Designing individualized neoantigen frameworks to activate host T-cell immunity.
Section 18 • Infrastructure

Our Technology Platform

Technology That Enables Precision: Precision medicine requires multiple technologies working together seamlessly.

Genomics

Understanding genetic variation and inherited disease susceptibility.

NGS

High-throughput sequencing and comprehensive genomic analysis.

Liquid Biopsy

Non-invasive molecular investigation through circulating biomarkers.

Bioinformatics

Computational processing, quality control, and variant interpretation.

AI

Advanced analysis and pattern discovery across complex biological datasets.

Molecular Diagnostics

Understanding disease biology at the fundamental molecular level.

Pharmacogenomics

Understanding genetic influences on individualized treatment response.